منابع مشابه
ESCRTs
hypothesis-driven research. I still relish the time when, as a naïve Ph.D. student, I was unaware of fashion and the need to please top journals. This allowed me to follow compulsively one aim, which I had convinced myself to be worthwhile. Other pieces of advice are to keep career plans flexible enough to allow collaborators to influence one's research direction and to synergise with local exp...
متن کاملESCRTs are everywhere.
The ESCRT proteins are an ancient system that buds membranes and severs membrane necks from their inner face. Three "classical" functions of the ESCRTs have dominated research into these proteins since their discovery in 2001: the biogenesis of multivesicular bodies in endolysosomal sorting; the budding of HIV-1 and other viruses from the plasma membrane of infected cells; and the membrane absc...
متن کاملNeuronal Functions of ESCRTs
The endosomal sorting complexes required for transport (ESCRTs) regulate protein trafficking from endosomes to lysosomes. Recent studies have shown that ESCRTs are involved in various cellular processes, including membrane scission, microRNA function, viral budding, and the autophagy pathway in many tissues, including the nervous system. Indeed, dysfunctional ESCRTs are associated with neurodeg...
متن کاملESCRTs and human disease.
The ESCRT (endosomal sorting complex required for transport) machinery plays a critical role in receptor down-regulation, retroviral budding, and other normal and pathological processes. The ESCRT components are conserved in all five major subgroups of eukaryotes. This review summarizes the growing number of links identified between ESCRT-mediated protein sorting in the MVB (multivesicular body...
متن کاملPiecing together the ESCRTs.
High-resolution structural analysis has characterized nearly all of the individual domains of ESCRT (endosomal sorting complex required for transport) subunits, all of the core structures of the soluble complexes and many of the interactions involving domains. Recent emphasis in structural studies has shifted towards efforts to integrate these structures into a larger-scale model. Molecular sim...
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ژورنال
عنوان ژورنال: Nature Cell Biology
سال: 2020
ISSN: 1465-7392,1476-4679
DOI: 10.1038/s41556-020-0557-1